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Joint Pain Relief Update

By John Parrillo

We’re hearing a lot more on TV commercials about products to relieve aches and pains, particularly in the joints. No wonder – people are living longer (that’s good) but with longevity often comes joint problems (that’s bad).

Generally, the management and treatment of joint problems are based on the use of anti-inflammatory drugs and pain killers, surgery, and rehabilitation. However, nutritional intervention, including supplementation, represents an ongoing and preferred strategy for managing and preventing joint pain.

The latest news in joint treatment is that it’s not a single supplement that works best, but rather a combination of supplements. One example from science: According to a review study published in 2016, using glucosamine sulfate and chondroitin sulfate (found in our Joint Formula™) to improve pain and stiffness is accented when taken in conjunction with fish oil found in our Fish Oil DHA 800 EPA 200™). (1)

So if you’re popping over-the-counter pain relievers like crazy, you may want to stop it – and stop the pain by employing a strategy of taking several natural supplements for relief. Here’s what I suggest:

Front-Line Joint Pain Relief

Glucosamine and Chondroitin 

Glucosamine is an important building block required by the body to manufacture molecules called glycosaminoglycans, which are found in human cartilage. Chondroitin accelerates the repair of joints by serving as a building block for cartilage. It also holds water, allowing nutrients to pass easily through cartilage. This is important because cartilage has no blood supply running through it. Both glucosamine and chondroitin work through pathways that regulate inflammation, cartilage manufacture, and immunity. 

Most studies with these substances have been favorable, particularly in the treatment of osteoarthritis (OA), the wear and tear of the joints that takes place with age and impact trauma (even exercise) on the joints. Research shows that glucosamine and chondroitin improve pain, help maintain the integrity of the joints, and stimulate the rebuilding of cartilage. (2)

So if you’re walking around with aching, inflamed joints, it’s time to start supplementing with this stuff. 

Use our Joint Formula™ to obtain these nutrients. The daily usage is two tablets a day.

Shark Cartilage

Our Joint Formula™ also contains shark cartilage, which has pain-relieving and anti-inflammatory properties. It been shown to ease two serious types of arthritis: rheumatoid arthritis, a chronic, systemic autoimmune disorder in which the immune system attacks the joints and causes inflammation and joint destruction; and osteoarthritis, a wear-and-tear disease that causes the breakdown of joints and bone. These benefits demonstrate that shark cartilage has a great potential in treating arthritic diseases. 

The mechanism behind shark cartilage’s success against arthritis primarily lies in the complex carbohydrates it contains, called mucopolysaccharides, which relieve the chronic and painful inflammation that curses so many arthritis sufferers. Shark cartilage is also a source of fish collagen, which contributes to joint health.

Shark cartilage is appropriate for bodybuilders, exercisers, and other athletes for joint protection – and can be considered as a recovery supplement. Intense training, whether from pounding weights or the pavement or aerobics floor, can produce skeletal muscle and joint damage that involves a subsequent inflammatory response. (Some inflammatory response is okay; too much isn’t.) The use of cartilage could thus enhance your recovery process. A faster recovery means you can get back into training sooner and hit it hard. The protective and anti-inflammatory effects of shark cartilage should not be ignored. 

Fish Oil (Omega-3 Fatty Acids)

Found in fatty fish and specific dietary supplements, omega-3s are a special type of dietary fat that perform a number of positive functions with regard to joint health. These benefits include reducing joint pain, easing morning stiffness, and helping people cut back on the use of nonsteroidal anti-inflammatory drugs.

Recently, scientists discovered exactly how fish oil works this magic. Fish oil contains metabolic byproducts called resolvins. They work by promoting restoration of normal cellular function following the inflammation that occurs after tissue injury (like you’d have after workouts). (3) So basically, they turn off inflammation and enhance tissue health.

Fish oil is thus a potent natural remedy for joint problems. In addition to eating fish, a good move is to take omega-3s in supplement form. Parrillo Performance offers its omega-3 supplement: Fish Oil DHA 800 EPA 200™. It is a natural marine-lipid concentrate that contains omega-3 fatty acids in medically recommended concentrations. We suggest one to three servings daily with your meals. 

Evening Primrose Oil™

Another good joint supplement is evening primrose oil™ (EPO), made from the seeds of a plant native to North America. EPO is the richest source of gamma linolenic acid (GLA), one of the EFAs. 

EPO has an anti-inflammatory action on joints that might be affected by various types of arthritis. There is moderate evidence that EPO affords some benefit in relieving symptoms of rheumatoid arthritis and osteoarthritis.

Our supplement is Evening Primrose Oil™. Each 1000 mg gel cap contains 30 IUs’s of vitamin E, 100 mg of Gamma Linolenic Acid and 760 mg of Linoleic Acid. We recommend taking one to three capsules daily – then notice how some of your most troublesome conditions start to disappear.

Second-String Relief

To further ease joint pain, I suggest you supplement with the following nutritional supplements:


Emerging research shows that taking antioxidant vitamins protects against joint problems. This is because joint tissue and cells can be damaged by free radicals that swarm the body. Antioxidants neutralize these cellular destroyers and render them incapable of doing damage.

The key benefit with antioxidant supplementation with regard to joints is that it supports the action of the supplements mentioned above. A 2018 study in  Nutrition Research concluded that oral supplementation with antioxidant vitamins combined with fish collagen (such as shark cartilage), chondroitin, and glucosamine significantly improved the clinical parameters related to joint health, and therefore, might be an effective solution to slow down the hallmarks of age-related joint problems.

To obtain these joint healing benefits, I suggest supplementing with our Vitamin Formula (which contains antioxidants) and Parrillo Bio-C (our antioxidant vitamin C supplement)

Vitamin C also helps build a strong immune system and is involved in the production of collagen, a protein building block cartilage that supports joints, skin and blood vessels. Take one or more tablets, preferably with meals.

Take our Parrillo Essential Vitamin Formula™ with each meal, as well.


Found in our Enhanced GH Formula™ and our Ultimate Amino Formula™, arginine has some very impressive joint healing benefits for bodybuilders, weight trainers, athletes, and exercisers. The main reason I recommend it in a joint-healing strategy is because it is a nitric oxide (NO) booster.

Nitric oxide is a molecule produced naturally in the body that helps to relax and expand blood vessels (vasodiation). Arginine has been well studied for its ability to contribute to NO production. In fact, arginine is the only building block for NO. (Don’t confuse nitric oxide with nitrous oxide, or laughing gas.) NO’s effects depend on a sufficient supply of arginine in your body. 

Because NO dilates your blood vessels, more blood flows through to your joints. And blood carries oxygen and nutrients, indirectly helping to heal joint tissue.

With our Ultimate Amino Formula, we recommend that you take two or more capsules of this supplement with each meal. The best way to take Enhanced GH Formula™ is on an empty stomach, first thing in the morning, right before a workout, and before bed.

There you have it – a joint healing and recovery strategy based on targeted supplementation. This strategy will help protect, restore, and renew your joints – no matter your age or level of conditioning.


1. Castrogiovanni, P. et al. 2016. Nutraceutical Supplements in the Management and Prevention of Osteoarthritis. International Journal of Molecular Sciences 17: 20142.

2. Kirkham, S.G., and Samarasinghe, R.K. 2009. Review article: Glucosamine. Journal of Orthopedic Surgery 17: 72–76. 

3. Souza, P.R., and Norling, L.V.  2016. Implications for Eicosapentaenoic Acid- and Docosahexaenoic Acid-Derived Resolvins as Therapeutics for Arthritis. European Journal of Pharmacology 15: 165-173.

4. Czajka, A., et al.  Daily Oral Supplementation with Collagen Peptides Combined with Vitamins and Other Bioactive Compounds Improves Skin Elasticity and Has a Beneficial Effect on Joint and General Wellbeing. Nutrition Research 57: 97-108.

2019-12-09T00:51:19-05:00 December 9th, 2019|by John Parrillo, The Press|

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